MOTS-c is a naturally occurring mitochondrial-derived peptide that has been studied in the field of molecular biology, cell metabolism, mitochondrial science, and peptide signaling. With the growing popularity of mitochondrial science, researchers are investigating the nature of MOTS-c in order to learn more about how small peptides function in complex cellular communication processes.
Certificate of Analysis
Batch PA-0095 — 10mg
View COA
Research Grade Quality
Independently Tested
MOTS-c
$79.99
Size / Strength
HPLC Verified
COA Included
Fast Dispatch
Discreet Shipping
100% Quality Guarantee
Every batch of MOTS-c is independently third-party tested. 30-day money-back guarantee — no questions asked.
Product Description
In contrast to the conventional nuclear-encoded peptides, MOTS-c is synthesized by mitochondrial DNA and falls under the category of mitochondrial derived peptides (MDP). Scientific research on MOTS-c includes the use of the peptide as an experimental model to study mitochondria signaling, cell response to stress, and metabolic pathways.
At Peptides Australia, MOTS-c 10mg/20mg is offered solely as a Research Use Only (RUO) laboratory reagent that is meant for research, analysis, and education purposes only. All of our batches are accompanied with relevant quality documentation that includes analytical data and Certificates of Analysis (COA).
Research Highlights
- Independent Laboratory Tested
- Batch-Specific Certificate of Analysis
- Australia-Wide Dispatch
- Research Use Only
- HPLC Tested Peptide Material
What is MOTS-c?
MOTS-c is a mitochondrial derived peptide which is made up of 16 amino acids.
It was discovered by scientists to be a peptide that exists in the mitochondrial DNA genome. It was an expansion in the knowledge about mitochondria in that it shed light on mitochondria in relation to molecular communication, apart from being involved in energy metabolism only.
Some of the cellular processes involving mitochondria include:
- Energy metabolism studies
- Cell signaling
- Pathway biochemistry
- Molecular communication
Studies into MOTS-c revolve around how the mitochondrial derived peptides take part in the above-mentioned cellular processes.
Scientific Background
Traditionally, mitochondria have been researched only in terms of their function in energy production by cells. Nevertheless, due to the advancements in molecular biology, it became known that mitochondria can produce signaling molecules that can affect cell-to-cell communications.
Mitochondrial-derived peptides represent an emerging research area in science.
The aim of scientists researching mitochondrial-derived peptides is to find out more about:
- Mitochondrial gene expression
- Peptide signaling pathways
- Cellular adaptive responses
- Molecular interactions
One of the mitochondrial-derived peptides researched by scientists in this field is called MOTS-c.
Classification of Mitochondrial-Derived Peptides
MOTS-c is one of the peptides classified as synthetic research peptides based on the sequence of mitochondrial-derived peptides.
Main features of such peptides include:
- A short amino acid sequence
- Mitochondrial origins
- Laboratory synthesis
- Use in research
Study of peptides enables researchers to look into the contribution of small biological molecules to cellular mechanisms.
Molecular Characteristics of MOTS-c
Research of peptide composition is crucial in peptide laboratory research.
MOTS-c has an amino acid sequence analyzed by scientists in order to understand its properties.
Stability Factors
The stability of a peptide can depend on certain environmental factors.
Typically, researchers investigate such factors as:
- Temperature exposure
- Moisture level
- Light exposure
- Packaging conditions
- Storage time
Proper storage conditions ensure the preservation of the quality of research materials.
Researchers may find useful educational information about:
- Peptide purity
- Reading a certificate of analysis
- Peptide storage guidelines
Why MOTS-c is Studied by Researchers
The scientific interest in MOTS-c is associated with its status as a peptide mitochondrial model.
Researchers focus on studying molecular mechanisms, not developing treatments.
Mitochondria Biology Research
Mitochondria are complex organelles, which play an important role in a variety of biological reactions.
Researchers study mitochondrial biology for understanding:
- Communication
- Molecular regulation
- Energy pathways
- Organelle signaling
Research on MOTS-c adds to general research on the involvement of mitochondria in biological processes.
Cellular Metabolism Research
The cellular metabolism is a complex process of interlinked biochemical reactions required for cellular activities.
In the metabolic research models, scientists study MOTS-c to understand:
- Signalling pathways in cells
- Responses at the molecular level
- Biochemical interactions
- Metabolic control mechanisms
Such studies help in improving knowledge about cellular biology.
Investigation of AMPK Signalling Pathways
One of the areas of scientific interest that involves MOTS-c is the connection of MOTS-c to cellular signalling pathways research, such as the AMPK-related pathway.
The AMPK is an important molecule of cellular signalling, studied in molecular biology.
Scientists study AMPK-related pathways in order to understand:
- Cellular communication
- Signalling processes associated with energy
- Molecular regulation
The research on MOTS-c serves as a laboratory model for studying such pathways.
Research on Mitochondrial Stress Responses
Another field where scientists study mitochondria-derived peptides is cellular stress research.
Scientific studies can include:
- Pathways of molecular adaptation
- Cellular signalling responses
- Peptide interactions
- Mitochondrial communication
Experimental Research Models
MOTS-c can be investigated using laboratory methods, which include:
- Molecular investigation
- Cell models
- Biochemistry testing
- Analytical characterization
The aim of such studies is to advance the science of mitochondrial peptides.
Production & Quality Control
Reliable research peptides have to be made through controlled manufacturing and analytical procedures as well as detailed documentation.
MOTS-c 10mg/20mg is a synthetic peptide research compound that is manufactured using peptide chemistry methods, which are intended to provide consistency and traceability and allow laboratory analysis.
Peptide production focusing on quality involves several steps to verify:
- Peptide identity
- Molecular consistency
- Analytical features
- Batch traceability
Such procedures help researchers to get essential information during laboratory research of peptides.
Solid Phase Peptide Synthesis (SPPS)
Most synthetic peptides used in research are manufactured using Solid Phase Peptide Synthesis (SPPS).
SPPS is a laboratory procedure allowing the assembly of amino acids in a controlled order and a certain peptide structure.
The general production scheme includes the following stages:
- Peptide sequence preparation
- Amino acid assembly
- Chemical cleavage and treatment
- Purification
- Analysis
- Lyophilization
- Batch documentation
Such an approach allows manufacturers to produce defined peptide structures for laboratory research.
Purification Process
Post-synthesis, the purification process is conducted to isolate the desired peptide from impurities.
Purification helps eliminate:
- Incomplete peptide molecules
- Synthesis reagents
- Associated molecules
- Production byproducts
Good quality purification helps enhance analytical analysis and consistency in batches.
Lyophilisation Process
Following the purification and analytical analysis, the MOTS-c is formulated in a lyophilized powder form.
Lyophilization is a procedure that is meant to freeze and dry with an aim of minimizing moisture content.
Advantages of this form include:
- Moisture reduction
- Stability enhancement
- Documentation convenience
- Process control
Research scientists should apply the appropriate laboratory protocols for lyophilized peptide storage and management.
Research Use Only (RUO)
Peptide Australia MOTS-c 10mg/20mg is available only as a Research Use Only (RUO) laboratory material.
This peptide is meant to be used exclusively for:
- Scientific research
- Lab analyses
- Scientific education
- Controlled experiments
MOTS-c peptide is not approved for therapeutic, diagnostic, veterinary and human use in Australia.
Research Materials and Approved Medicines
Research materials and approved medicines are different.
Medicine approval process involves:
- Safety evaluation
- Clinical trials
- Manufacturing approval
- Approved usage
Research peptides are provided for scientific research only.
Responsibility for Laboratory Research
Researchers and organisations utilising RUO materials must ensure compliance with:
- Requirements of the institution
- Laboratory safety guidelines
- Research governance guidelines
- Relevant Australian regulations
MOTS-c should be utilised only in relevant laboratory settings and by suitable personnel.
Why Choose Peptides Australia?
A reliable peptide research process requires reliable documentation, supply and analysis information.
Peptides Australia delivers reliable research materials accompanied by reliable documentation for:
- Universities
- Biotech companies
- Research laboratories
- Scientific institutions
Batch-Specific Certificate of Analysis
Batch-specific COAs provide analytical information for products. These documents are important for:
- Laboratory documentation
- Materials verification
- Research traceability
Independent Laboratory Testing
Analytical testing allows researchers to analyse:
- Peptide identity
- Purity properties
- Batch consistency
HPLC Tested Peptides
The HPLC test will deliver analytical information regarding the peptide composition and purity.
Secure Packaging
Proper packaging is used to ensure the protection of lyophilised peptide materials during transportation and storage.
Australia-wide Dispatch
Reliable delivery will allow researchers to utilise material for:
- Research institutions
- Universities
- Biotech companies
- Scientific researchers
Researchers thinking of purchasing MOTS-c in Australia must check out the specifications of the product, availability of Certificate of Analysis, analytical testing information and Research Use Only status.
Research Use Only
This product is intended solely for laboratory research purposes. Not for human consumption.
Storage & Handling
Storage & Laboratory Handling Guidelines
Appropriate storage and handling practices are essential for ensuring the quality of peptides. MOTS-c is provided in a lyophilized form and therefore requires proper handling in the lab.
Temperature Considerations
Researchers need to take into account appropriate storage conditions. Key points are:
- Storage under recommended conditions
- Avoidance of any temperature changes
- Proper protection during transport
Moisture Protection
Lyophilised peptides should be preserved from moisture content.
Good laboratory practices could consist of:
- Correctly sealing containers
- Limiting exposure to humidity
- Adhering to suppliers' suggestions regarding preservation
Light Protection
Scientists should think about protecting peptide products from direct light exposure. A good controlled environment preserves consistency of research materials.
Laboratory Documentation
Scientific laboratories typically keep documentation on:
- Batch data
- Preservation details
- Product data
Experimental techniques
Documented information ensures good laboratory practices and a research quality system.
Scientists can consult further sources, such as:
- Guidelines for Peptide Preservation
- How to Interpret Certificate of Analysis
- Laboratory Quality Control
Full Technical Specifications
Every batch of MOTS-c is independently analysed before dispatch. The values below describe the current research batch.
| Product Name | MOTS-c |
|---|---|
| CAS Number | 1627580-64-6 |
| Molecular Formula | C₁₀₁H₁₅₂N₂₈O₂₂S₂ |
| Molecular Weight | 2174.6 g/mol |
| Quantity / Strength | 10mg | 20mg |
| Purity | ≥ 99% (HPLC) |
| Form | Lyophilised Powder |
| Appearance | White Lyophilised Powder |
| Batch Number | PA-0095 |
| Storage Conditions | 2°C-8°C (Refrigerated) |
| Category | Longevity & Anti-Aging |
| Intended Use | Research Use Only — not for human consumption |
Certificate of Analysis
Every batch of MOTS-c is independently tested before dispatch. View the full COA for the current batch below.
Certificate of Analysis (COA)
Batch Number PA-0095
≥ 99%
Purity
HPLC
Confirmed
Identity
Mass Spec
Pass
Heavy Metals
ICP-MS
| COA Information | Purpose |
|---|---|
| Product Name | Confirms peptide identification |
| Batch Number | Supports traceability |
| Purity Results | Provides analytical evaluation |
| Testing Method | Identifies laboratory techniques |
| Identity Testing | Supports molecular confirmation |
| Quality Review | Documents assessment |
Batch Traceability & Documentation
Batch traceability is one of the elements of ethical research peptide production.
Documentation relating to a peptide batch can contain:
- Peptide identification
- Batch number
- Analytical test results
- Quality specifications
- Storage guidelines
Batch traceability makes it easier for research organizations, universities, and laboratories to document the materials used in scientific experiments.
Purity Testing & Certificate of Analysis (COA)
Analytical testing gives research scientists details regarding the peptide structure, identity, and quality.
Before selecting laboratory peptides, researchers usually examine analytical documentation, which contains:
- Purity information
- Peptide identity
- Testing procedures
- Batch information
High-Performance Liquid Chromatography (HPLC)
High-Performance Liquid Chromatography (HPLC) is one of the widely applied techniques for determining peptide purity.
The technique is designed to separate the components in a mixture and generate a chromatogram that can be analyzed by scientists.
As to the research materials for MOTS-c, HPLC test results can include:
- Peptide purity percentage
- Main peptide peak
- Related substances
- Composition of the sample
- Consistency of batches
The use of HPLC in peptide chemistry and biotech laboratories is common.
Identity Test by LC-MS
Liquid Chromatography–Mass Spectrometry (LC-MS) can be widely applied in order to verify peptide identity.
LC-MS analysis will help researchers determine:
- Molecular mass
- Expected peptide identity
- Structure of the substance
In order to obtain additional information about research peptide materials, it is possible to apply complementary analytical techniques.
Scientists interested in testing methods for laboratory research can find information on the following topics:
- Understanding Peptide Purity
- HPLC vs LC-MS Testing
- Third-Party Laboratory Testing
What Is a Certificate of Analysis?
A Certificate of Analysis (COA) is an individual quality document of a research peptide batch.
A typical COA may include:
Certificate of Analysis allows researchers to get an insight into the technical specifications of lab products prior to undertaking their research work.
Researchers interested in buying MOTS-c from Australia need to consider Certificate of Analysis data, analytical data, and supplier quality standards before choosing laboratory peptides.
Research Disclaimer
For Research Use Only — Not for Human Consumption
This content is provided for educational, scientific and research-information purposes only. It does not provide medical advice, treatment recommendations or personal dosage instructions. Available evidence concerning MOTS-c includes preclinical research and ongoing or completed clinical investigations. Further research is required to better understand its safety, pharmacology and potential efficacy for specific research applications.
- Not for human or veterinary use
- No claims are made regarding safety or efficacy in humans
- Must be handled with appropriate laboratory safety equipment
- Purchaser assumes all responsibility for legal, compliant use
References
5 sources- 1Lee C, Zeng J, Drew BG, et al. The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance. Cell Metabolism. 2015;21(3):443-454.PubMed: https://pubmed.ncbi.nlm.nih.gov/25738459/
- 2Reynolds JC, Lai RW, Woodhead JST, et al. MOTS-c Is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis. Nature Communications. 2021;12:470. PubMed: https://pubmed.ncbi.nlm.nih.gov/33473109/PubMed: https://pubmed.ncbi.nlm.nih.gov/33473109/
- 3Lee C, Kim KH, Cohen P. MOTS-c: A Novel Mitochondrial-Derived Peptide Regulating Muscle and Fat Metabolism. Free Radical Biology and Medicine. 2016;100:182-187.PubMed: https://pubmed.ncbi.nlm.nih.gov/27216708/
- 4Wan W, Zhang L, Lin Y, Rao X, Wang X. Mitochondria-Derived Peptide MOTS-c: Effects and Mechanisms Related to Stress, Metabolism and Aging. Journal of Translational Medicine. 2023;21:36.PubMed Central: https://pmc.ncbi.nlm.nih.gov/articles/PMC9854231/
- 5Australian Government, Therapeutic Goods Administration (TGA). Concerns Regarding the Public Health Risks Associated with Unapproved Peptide Products. Therapeutic Goods Administration. 2026.TGA: https://www.tga.gov.au/news/media-releases/concerns-regarding-public-health-risks-associated-unapproved-peptide-products
Citations are provided for research reference and open in a new tab. Listing a study does not imply it evaluated this specific product.
Frequently Asked Questions
Researchers Also Purchase
Why Researchers Choose Us
Research-Grade Quality. Trusted by Researchers Across Australia.
Learn About Our QualityDiscreet Packaging
Fast Australia-Wide Delivery
Expert Support
30-Day Money Back